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Tag Archives: melanoma

Pigmented Spindle Cell Naevus of Reed: A Controversial Diagnostic Entity In Australia


Interesting article in the May 2011 edition of the Australasian Journal of Dermatology by Scott Webber, Greg Siller and Peter Soyer entitled ‘Pigmented Spindle Cell Naevus of Reed: A Controversial Diagnostic Entity In Australia.’

Points of note include

– Pigmented spindle cell naevus of Reed (PSCN) is a recognized distinctly separate entity away from Spitz naevus.

– The clinical and dermatoscopic features of Spitz naevi and melanoma overlap with PSCN.

– Clinical diagnosing of PSCN by dermatology training groups remains difficult.

– Well defined dermatoscopic and physical criteria for lesional morphology and histopathological characteristics are available and have increased the accuracy in distinguishing PSCN from Spitz naevi and melanoma.

– An accurate diagnosis is best gained from clinicopathological correlation.

– PSCN typically occurs in young women, only 25% of cases in patients > 30 years old.

– Punch biopsy as initial management is not recommended as misdiagnosis as melanoma is more likely.

I recommend reading the entire article. Below is a link.

http://onlinelibrary.wiley.com/doi/10.1111/j.1440-0960.2011.00743.x/abstract

Thanks for reading and I welcome any comments

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Lack of UV-A Protection In Daily Moisturising Creams


Came across another interesting article in the May edition of ‘The Archives of Dermatology’ 2011. The article is entitled ‘Lack of UV-A Protection In Daily Moisturising Creams’ on page 618.

Ultraviolet radiation (UV) contains UVA, UVB and UVC subtypes. The major source of UV exposure for humans is sunlight. The earths ozone layer blocks approximately 98% of all UV radiation and the 2% which reaches the earths surface 99% is of the UVA subtype. UVB can cause direct DNA damage whereas UVA causes indirect damage of DNA via the formation of free radicals. Therefore it is important any sunscreen solution contains both UVA and UVB filters.

This article reported the estimated long-range UVA1 protection of 29 creams.

Major points of note from the article include

– most daily facial creams contain ingredients known as UV filters claiming broad spectrum UV protection

– Sun protection factor (SPF) doesn’t reflect UV-A1 protection

– UVA penetrates window glass whereas UVB is blocked, therefore women working indoors need to protect themselves from UVA exposure

– of the 29 creams 6 didn’t contain any UVA1 filters

I recommend reading the full article as it is an interesting read. Below is a link to the article.

Lack of UV-A Protection in Daily Moisturizing Creams
Steven Q. Wang; Jacqueline M. Goulart; Henry W. Lim
Arch Dermatol. 2011;147(5):618-620

Thanks for reading and I welcome any comments.

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Persistent Melanocytic Nevi: A Review and Analysis of 205 cases


Great article in the June 2011 issue of the ‘Journal of Cutaneous Pathology’ regarding persistent melanocytic naevi. Good reading for those interested in the subject.

Things of note are

– female predominance (reason unclear)

– back is the most common site followed by abdomen then chest

– mean time between original biopsy then biopsy of persistent naevus was 9.7 months

– dysplastic naevi were most likely to recur

– persistent melanocytic naevi were more likely to be initially removed via shave biopsy

 

Link to the article below

http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0560.2011.01692.x/abstract

Thanks for reading and I welcome any comments

Keep an eye out for my website COMING SOON (www.skinpathonline.com)

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Melanoma Research – Sex differences in survival of cutaneous melanoma are age dependent


Came across an interesting article in the latest issue of the Melanoma Research journal regarding differences in survival rates based on sex. It has been previously observed that women have a better survival rate for melanoma than men. This has also been observed in other cancers such as lung adenocarcinoma and colon cancer.

The study reveals that the slight survival benefit women with melanoma experience, disappears after the age of 60. This is mirrored, but also conflicts with other studies referenced within the article.

Proposed reasons for this female survival benefit include women being more prudent in the personal examination of the skin, women having a greater percentage of lower limbs melanomas which are associated with a better prognosis and immune gender differences.

Below is a link to the article abstract

http://journals.lww.com/melanomaresearch/Abstract/2011/06000/Sex_differences_in_survival_of_cutaneous_melanoma.11.aspx

 I recommend getting the whole article if it is possible.

 Thanks for reading and I welcome any comments.

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Cutaneous Squamous Cell Carcinoma – Overview


Squamous cell carcinoma (SCC) is defined by the World Health Organisation as ‘a malignant neoplasm of epidermal (and mucous membrane) keratinocytes in which the component cells show variable squamous differentiation.’

Most SCCs appear on the areas of the skin which get the most sun exposure though this is not the only place which the can arise. SCCs can also arise on mucosal areas such as on the lip. Patients who have a pale complexion and those who do not tan readily are at a greater risk. SCC is very uncommon in the Black population.

The most important causative agent is sun exposure, more correctly UVB radiation. Others factors that have been incriminated include human papilloma virus (HPV) infection, ulcers, immunosuppression and radiotherapy. Patients with organ transplants are also at a greater risk. SCC can be fatal in some cases (most commonly found in Australia) giving rise to the notion that sun exposure, which causes DNA damage and also suppresses the skin immune system, plays a lead role in the cause of aggressive SCCs.

As sun exposure is the major cause factor of SCC, it is no surprise that the forehead, ears, scalp, face, neck, back of the hands and lips are the most common places to find SCCs on the human body.

SCCs commonly appear as plaques/nodules with an elevated/indurated, crusty surface. The areas immediately surrounding the SCC show the typical signs of sun damage.

I have previously blogged about the prognostic factors of SCC, please click on the link to see more (Prognostic Factors of Cutaneous Squamous Cell Carcinoma)

Thanks for reading and I welcome any comments.

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Solar Keratosis and It’s Subtypes


Solar Keratosis is defined by the World Health Organization as ‘a common intraepidermal neoplasm of sun-damaged skin characterized by variable atypia of keratinocytes.’

Subtypes that are recognised are hypertrophic, atrophic, acantholytic, pigmented. lichenoid and bowenoid. All subtypes usually display the common features of hypogranulosis, parakeratosis along with keratinocyte atypia confined to the bottom two layers of the epidermis (basal and spinous). Below is some of the histological features commonly seen in the subtypes apart from the features mentioned above.

HYPERTROPHIC

This variant exhibits hyperkeratosis, acanthosis, papillomatosis, rete ridge elongation, telangiectasia and parakeratosis. The parakeratosis can be seen alternating with the hyperkeratosis.

ATROPHIC

This variant exhibits epidermal atrophy, basal epidermal budding with adnexal extension

LICHENOID

This variant exhibits exocytosis, keratinocytic vacuolation, keratinocytic apoptosis, colloid bodies, band-like superficial dermal lymphocytic infiltrate and pigment incontinence.

ACANTHOLYTIC

This variant exhibits acantholysis (with possible extension down adnexae), suprabasal clefting and dyskeratosis.

PIGMENTED

This variant exhibits increased pigmentation of atypical keratinocytes with associated dermal melanophages.

BOWENOID

Although most pathologists consider this Bowen’s disease, some say bowenoid solar keratosis exhibits less than full thickness atypia and sparing of follicles.

Thanks for reading.

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Non-melanoma skin cancer (NMSC) treatments


Below are the most common treatments available, plus a brief description, once a NMSC has been diagnosed (usually a basal cell carcinoma or a squamous cell carcinoma).

Surgical excision (standard) – the most common and preferred form of treatment. Good for nodular tumours with a sharply demarcated border. Has a high cure rate and is dependent on the closeness of tumour to the resection margin in regards to the pathology (ie. the closer the tumour is to the margin the more likely it is to recur). One let down is the bread loafing technique which results in only approximately 5% of the actual margins being visualised by the pathologist for assessment of complete excision.

Moh’s /  Moh’s Micrographic Surgery – form of treatment with the highest reported cure rate (~97-99%). This technique results in the entire peripheral margins and the deep margins being visualised and assessed for completeness of excision (this is why the cure rate is so high). One let down is the time-consuming nature of the technique and the specialised training that is involved.

Topical chemotherapy – the most common available topical chemotherapy agents include 5-fluorouracil (5-FU) and 5% imiquimod. Generally speaking 5-FU works by inhibiting DNA replication therefore the growth of the tumour and imiquimod works by modifying the local tumour immune response of the patient. Advantages include the non-invasiveness topical therapy. Disadvantages are that, used alone, they can only be used on superficial tumours and not invasive tumours. Experimentation of their use in conjunction with other treatments (eg. curettage then topical treatment, or topical use to reduce tumour size before excision) have resulted in reports of higher cure rates.

Curettage +/- Electrodissection – put simply the tumour is physically scrapped away then the treated area is exposed to an electrical current which results in the softening of the skin and the procedure is repeated until the treating physician is satisfied excision is complete. The curettage portion technique can be applied alone without the electrodissection. This technique is usually reserved for site which are cosmetically unimportant (eg back). The cure rate is dependent on how aggressive the technique is applied (ie. the more the aggressive the higher the cure rate) and the growth type of the tumour being treated (ie. the more invasive the tumour the lower the cure rate).

Cryotherapy – one of the older treaments for NMSC which involves treatment of the tumour most commonly with liquid nitrogen. Cure rate can be high but there is reduced tumour margin control resulting in a higher recurrence rate.

Photodynamic Therapy (PDT) – fairly new technique which involves applying a topical photosensitizer to the target tumour and then exposure of the target area to light. This results in the production of aggressive chemicals which damage the cell causing death. Disadvantages include the ineffectiveness on invasive and thicker tumours due to lack of light penetration, and high cost. Advantages include the non-invasiveness of the technique.

Radiotherapy – usually reserved for older patients or where the surgical removal of the tumour is not a viable option. Has a reported cure rate of approximately 80-95%. Tumours recurring after radiotherapy are generally more aggressive and can become radiotherapy resistant.

I welcome any comments or other therapies you have encountered.

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